John Lewis Scott is the son of the late Isaac H. Scott, Jr., and Randell Gunn Scott. He is the grandson of the late Novella Peters Scott and Isaac Scott, Sr. John Lewis is married to Dr. Cassie Luke. His siblings are:
Ida Carrie Scott Daniels (married to Jerry Daniels)
Calvin Leon Scott (married to Johnnie Mae Stinson Scott)
Milford Scott (married to Annette Edwards Scott)
Mildred Scott (married to Dr. Carl Cheeks)
Beatrice R. Scott Coley (married to John E. Coley)